New Data Show Benefit of Tagrisso in Patients with EGFR-mutated Non-small Cell Lung Cancer and Central Nervous System Metastases

Phase III FLAURA trial demonstrates 52% risk reduction of CNS disease progression or death in patients treated with Tagrisso (osimertinib) compared to current standard-of-care EGFR-TKIs*

CAMBRIDGE, England--(BUSINESS WIRE)--AstraZeneca today presented new data from a subgroup analysis of the Phase III FLAURA trial, which explored osimertinib as 1st-line therapy in patients with locally advanced or metastatic epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). Results presented at the ESMO Asia 2017 Congress in Singapore showed that patients with central nervous system (CNS) metastases at baseline had a higher objective response rate with their brain metastasis and suggest a lower risk of CNS progression when treated with osimertinib, a third-generation, irreversible EGFR tyrosine kinase inhibitor (TKI), versus current standard-of-care EGFR-TKIs (erlotinib or gefitinib) [Abstract LBA5].1


The analysis included patients with ≥1 measurable and/or non-measurable CNS lesion present on baseline scan (as assessed by blinded independent central review), accounting for 23% of the total FLAURA patient population (128 of 556 patients; 61 patients enrolled in the osimertinib arm and 67 patients in the comparator arm).1 In this pre-specified subgroup analysis, osimertinib demonstrated a nominally statistically significant improvement in CNS progression-free survival (PFS) compared with current standard of care, reducing the risk of CNS disease progression or death by more than half (hazard ratio 0.48; 95% confidence interval [CI] 0.26-0.86; nominal p=0.014).1 In addition, fewer patients in the osimertinib arm experienced disease progression due to the development of new CNS lesions, compared with patients in the comparator arm (12% vs. 30%).1 The CNS objective response rate (a measurement of tumour shrinkage) was also higher in patients treated with osimertinib at 66% vs. 43% for patients in the comparator arm (odds ratio 2.5; 95% CI 1.2, 5.2; p=0.011).1

The FLAURA safety data for osimertinib were in line with those observed in prior clinical trials.1,2 Osimertinib was well tolerated, with less frequent Grade 3 or higher adverse events (AEs) than with standard EGFR-TKIs (34% vs. 45%). In patients treated with osimertinib, the most common AEs were diarrhoea (58% [2% Grade ≥3]) and dry skin (32% [<1% Grade ≥3]), and in the comparator arm group, the most common AEs were diarrhoea (57% [3% Grade ≥3]) and dermatitis acneiform (48% [5% Grade ≥3]).2

Dr. Johan Vansteenkiste, Respiratory Oncologist at the University Hospital KU Leuven, Leuven, Belgium, said: “CNS metastases, including brain metastases, are a common and very disabling complication of advanced EGFR mutation-positive NSCLC. They are notoriously difficult to treat, as existing oral therapies are often unable to effectively cross the blood-brain barrier. The CNS efficacy results for osimertinib in the FLAURA trial suggest improved clinical outcomes in an area of great unmet medical need.”

Sean Bohen, Executive Vice President, Global Medicines Development and Chief Medical Officer at AstraZeneca, said: “Osimertinib represents the next generation of targeted therapies in EGFR mutation-positive NSCLC, and its CNS activity has been demonstrated in the AURA3, BLOOM and FLAURA trials. This subgroup analysis of FLAURA further supports data presented earlier this year in demonstrating the consistent benefit of osimertinib when used as a 1st-line therapy, irrespective of the presence of CNS metastases at study entry.”

Full results of the FLAURA trial were published online today in the New England Journal of Medicine (NEJM).

*

Risk reduction was nominally statistically significant

– ENDS –

NOTES TO EDITORS

About NSCLC
Lung cancer is the leading cause of cancer death among both men and women, accounting for about one-quarter of all cancer deaths, more than breast, prostate and colorectal cancers combined.3 Approximately 10-15% of patients in the US and Europe, and 30-40% of patients in Asia have EGFR mutation-positive (EGFRm) NSCLC.4,5,6 These patients are particularly sensitive to treatment with currently available EGFR-TKIs, which block the cell-signaling pathways that drive the growth of tumour cells.7 However, tumours almost always develop resistance to EGFR-TKI treatment leading to disease progression.8 Approximately half of patients develop resistance to approved EGFR-TKIs such as gefitinib and erlotinib due to the resistance mutation, EGFR T790M. Osimertinib also targets this secondary mutation that leads to disease progression.8,9 There is also a need for medicines with improved CNS efficacy, since approximately 25% of patients with EGFR-mutated NSCLC have brain metastases at diagnosis, increasing to approximately 40% within two years of diagnosis.10

About Tagrisso
Tagrisso (osimertinib) is a third-generation, irreversible EGFR-TKI designed to inhibit both EGFR-sensitising and EGFR T790M-resistance mutations, with clinical activity against CNS metastases.11 Osimertinib 40mg and 80mg once-daily oral tablets have been approved in more than 60 countries, including the US, EU, Japan and China, for patients with EGFR T790M mutation-positive advanced NSCLC. Osimertinib is also being investigated in the adjuvant setting and in combination with other treatments.12,13

About FLAURA
The FLAURA trial assessed the efficacy and safety of osimertinib 80mg once daily vs. standard-of-care EGFR-TKIs (either erlotinib [150mg orally, once daily] or gefitinib [250mg orally, once daily]) in previously untreated patients with locally advanced or metastatic EGFR-mutated NSCLC.2 The trial was a double-blinded, randomised study, with 556 patients across 29 countries.2

About AstraZeneca in Lung Cancer
AstraZeneca is committed to developing medicines to help every patient with lung cancer. We have two approved medicines and a growing pipeline that targets genetic changes in tumour cells and boosts the power of the immune response against cancer. Our unrelenting pursuit of science aims to deliver more breakthrough therapies with the goal of extending and improving the lives of patients across all stages of disease and lines of therapy.

About AstraZeneca in Oncology
AstraZeneca has a deep-rooted heritage in Oncology and offers a quickly-growing portfolio of new medicines that has the potential to transform patients’ lives and the Company’s future. With at least six new medicines to be launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, we are committed to advance New Oncology as one of AstraZeneca’s five Growth Platforms focused on lung, ovarian, breast and blood cancers. In addition to our core capabilities, we actively pursue innovative partnerships and investments that accelerate the delivery of our strategy, as illustrated by our investment in Acerta Pharma in haematology.

By harnessing the power of four scientific platforms – Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response and Antibody Drug Conjugates – and by championing the development of personalised combinations, AstraZeneca has the vision to redefine cancer treatment and one day eliminate cancer as a cause of death.

About AstraZeneca
AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Oncology, Cardiovascular & Metabolic Diseases and Respiratory. The Company also is selectively active in the areas of autoimmunity, neuroscience, and infection. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

For more information, please visit www.astrazeneca.com and follow us on Twitter @AstraZeneca.

Intended audiences
This press release is issued from AstraZeneca Corporate Headquarters in Cambridge, UK and is intended to provide information about our global business. Please be aware that information relating to the approval status and labels of approved products may vary from country to country, and a country-specific press release on this topic may have been issued in the countries where AstraZeneca conducts business. Osimertinib is not yet licensed for the 1st-line treatment of EGFRm NSCLC anywhere in the world.

References

1 Vansteenkiste J, et al. CNS Response to Osimertinib Vs. Standard-of-Care EGFR-TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA. Presented at the European Society of Medical Oncology (ESMO) Asia 2017 Congress, 17-19 November 2017, Singapore.

2 Ramalingam S, et al. Osimertinib vs SoC EGFR-TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC (FLAURA). Presented at the European Society for Medical Oncology (ESMO) 2017 Congress, 8-12 September 2017, Madrid, Spain.

3 American Cancer Society. Key Statistics for Lung Cancer. Available at https://www.cancer.org/cancer/non-small-cell-lung-cancer/about/key-statistics.html. Accessed November 2017.

4 Szumera-Ciećkiewicz A, et al. EGFR Mutation Testing on Cytological and Histological Samples in Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence. Int J Clin Exp Pathol. 2013:6;2800-12.

5 Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27.

6 Ellison G, et al. EGFR Mutation Testing in Lung Cancer: a Review of Available Methods and Their Use for Analysis of Tumour Tissue and Cytology Samples. J Clin Pathol. 2013:66;79-89.

7 Langer CJ, et al. Epidermal Growth Factor Receptor Inhibition in Mutation-Positive Non-Small-Cell Lung Cancer: Is Afatinib Better or Simply Newer? J Clin Oncol. 2013:31(27);3303-05.

8 Yu HA, et al. Analysis of Tumour Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancer. Clin Cancer Research. 2013:19(8);2240-46.

9 Wu SG, et al. The Mechanism of Acquired Resistance to Irreversible EGFR Tyrosine Kinase Inhibitor Afatinib in Lung Adenocarcinoma Patients. Oncotarget. 2016:7(11);12404-13.

10 Rangachari, et al. Brain Metastases in Patients with EGFR-Mutated or ALK-Rearranged NonSmall-Cell Lung Cancers. Lung Cancer. 2015;88,108–111

11 Cross DAE, et al. AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer. Cancer Discov. 2014:4;1046-61.

12 National Institutes of Health. AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy (ADAURA). Available at: https://www.clinicaltrials.gov/ct2/show/NCT02511106. Accessed November 2017.

13 National Institutes of Health. AZD9291 in Combination With Ascending Doses of Novel Therapeutics. Available at: https://clinicaltrials.gov/ct2/show/NCT02143466. Accessed November 2017.


Contacts

AstraZeneca
Karen Birmingham: +44 781 852 4012
Ashley DiLeo: +1 301-398-1478
Hugues Joublin: +1 301-398-3041

Global Mountain Bike Market – Growth Analysis and Forecast |Technavio

LONDON--(BUSINESS WIRE)--#Automotive--The global mountain bike market is expected to grow at a CAGR of close to 10% during the forecast period, according to Technavio’s latest market research.



In this market research report, Technavio covers the market outlook and growth prospects of the global mountain bike market for 2017-2021. The report has further categorized the market into two end-user segments that include competition and leisure.

Technavio’s research analysts segment the global mountain bike market into the following regions:

  • Americas
  • EMEA
  • APAC

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Americas: largest global mountain bike market

Mountain biking is one of the off-road sports that is gaining popularity across North America. Cross-road biking is popular in this region due to the rising number of women and kids entering this sport as this sport is shifting from being male dominant to a leisure activity pursued by women and children. The popularity is increasing due to the rising awareness regarding safety, fitness, ethics, and environmental protection.

“Several cyclist organizations such as League of American Wheelman, IMBA, and Bike Centennial have initiated plans and projects to encourage more individuals to enter the sport. IMBA Canada, which is a subsidiary of the IMBA, aims at trail building expertise, convenient access to appealing trails, and political influence to increase the number of mountain riders in the local region,” says Ganesh Subramanian, a lead automotive manufacturing research expert from Technavio.

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Global mountain bike market in EMEA

During the forecast period, the mountain bike market in EMEA is expected to grow at a steady rate. The increasing demand for the mountain bike market is primarily driven by the introduction of electric mountain bikes used for leisure activities. As the battery in the electric bikes maximizes the power of the bike, it plays a crucial part in enhancing the rider’s experience. The efforts made, and initiatives taken by various mountain biking associations help to increase the awareness regarding this sport.

“Competitive mountain biking is an expanding industry in Europe. The Crankworx roster event of the global mountain bike festivals in Austria is a winter sports competition wherein the ride travels through downhill, dual speed, and style, slopestyle, whip off and pump tracks,” says Sushmit.

Global mountain bike market in APAC

During the forecast period, the mountain bike market in APAC is expected to grow at an exponential rate. The major factor contributing to the growth of the market in this region is the increase in buying power and disposable income of the people in developing countries such as China, India, Australia, and South Korea.

The sport has gained attention from bikers and adventure and fitness enthusiasts in India. This is because of the rapidly changing lifestyle and increasing mountain biking tourism in the region. The scenic and rugged landscapes such as mountains, high passes, deep valleys, and alpine glaciers, provide opportunities for the bikers to explore different terrains. In India, mountain bikers can explore several destinations such as Himachal, Ladakh, Garhwal, and Kumaon.

The top vendors in the global mountain bike market as highlighted in this market research analysis are:

  • Cannondale
  • Giant Bicycles
  • Pivot Cycles
  • SCOTT Sports
  • Trek Bicycle Corporation
  • TRINX
  • XDS BICYCLES

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With over 500 specialized analysts, Technavio’s report library consists of more than 10,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio’s comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

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APAC Tops the Global Home Broadband Wi-Fi Devices Market | Technavio

LONDON--(BUSINESS WIRE)--#ConnectedDevices--The latest market research report by Technavio on the global home broadband Wi-Fi devices market predicts a CAGR of more than 8% during the period 2017-2021.



The report segments the global home broadband Wi-Fi devices market by product (fixed solutions and portable solutions) and by geography (APAC, the Americas, and EMEA). It provides a detailed illustration of the major factors influencing the market, including drivers, opportunities, trends, and industry-specific challenges.

Here are some key findings of the global home broadband Wi-Fi devices market, according to Technavio ICT researchers:

  • Growth in wireless telecommunications: a key market driver
  • In 2016, the global wireless home broadband Wi-Fi devices market by fixed solutions dominated the market and was valued at USD 2.37 billion
  • APAC dominated the global home broadband Wi-Fi devices market in 2016
  • Cambium Networks, Huawei Technologies, NETGEAR, TP-Link Technologies, and ZTE are the key players

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Market growth analysis

One of the key drivers of the global home broadband Wi-Fi devices market is the growth in wireless telecommunications. Currently, wireless connectivity is the most preferred connectivity solution. Wireless connectivity has many benefits. It is cheaper than fiber or any other wired solution and is eco-friendly. In comparison with wired and fiber connectivity, wireless connectivity does not involve digging trenches or drilling through walls. Wireless technologies are evolving, and they offer multiple options to end-users in terms of portability. The cost of delivered data in case of wireless broadband data is continuously dropping due to large-scale adoption of the technology.

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Geographical analysis

According to Technavio researchers, APAC occupies the largest market share among all the regions and is also expected to show the fastest growth during the forecast period. There is a growth in high-speed Internet access and wireless broadband in this region. This is because of the presence of highly competitive markets players such as Airtel, Reliance Jio, China Mobile, and NTT DOCOMO in their respective countries of operation. With 3G and 3G+ platforms still covering the region, mobile broadband services are well-established. The growth is being reinforced by the lower prices of devices such as smartphones and tablets and reduced tariffs by network operators to support even wider adoption.

According to Jujhar Singh, a lead analyst at Technavio for research on machine to machine (M2M) and connected devices, “The licensing of 4G and the ongoing launch of 4G services across Asia have provided the fundamental platform for growth in wireless broadband services. 4G has also offered growth prospects for content providers and wireless access in domestic markets. In South Asia, people usually own cell phones and not PCs. This indicates the huge potential for the development of mobile data services.”

Competitive vendor landscape

The global home broadband Wi-Fi devices market is concentrated as some major players occupy a significant share of the market. The market is dominated by major players like Huawei Technologies, TP-Link Technologies, NETGEAR, ZTE, and Cambium Networks. There are many small-scale players, usually from countries in APAC, such as Japan and China, who have a certain impact on the market. Fixed solutions are the dominant form of product in the home broadband Wi-Fi devices market. However, the shift to portable solutions is imminent because of the constantly mobile and on-the-move nature of internet users. Portable solutions are also expected to grow faster than fixed solutions.

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About Technavio

Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions.

With over 500 specialized analysts, Technavio’s report library consists of more than 10,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio’s comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

If you are interested in more information, please contact our media team at media@technavio.com.


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Much-Anticipated CHTF 2017 Top 10 Products Are Unveiled

SHENZHEN, China--(BUSINESS WIRE)--#3DbioPrinter--The 19th China Hi-Tech Fair (CHTF 2017), with the theme of “Innovation-Driven Development and Supply Quality Upgrade”, is taking place from November 16 to 21 at Shenzhen Convention and Exhibition Center. On the afternoon of November 10, the CHTF 2017 Top 10 Products were unveiled at the awards ceremony by Mr. Gao Zimin, Vice Mayor of Shenzhen City.


A total of 322 entries competed for the honor Top 10 Products, and the voting lasted nearly 3 months. 60 candidate products in the fields of new energy, 3D print, flexible display, life sciences, unmanned vehicles and AI were shortlisted by the organizer, experts and media representatives and went for open voting online.

The final Top 10 Products all represent the most advanced technologies in their respective sectors: the water-making device that can make water out of air, the smart sportswear that can monitor heartbeat and other health data, the 3D bio-printer that can print a functioning ovary, the clean energy air-conditioning station, the smart security system for kids, the 6.01-inch full screen, the flexible fast-charge battery, the 3-G gene sequencer, the automatic pilot level 4 solution, and anti-haze window screen.

Also unveiled at the ceremony were the “Top 8 Eye-Catching Products” which represent the taste of the public. Winners included the 3D motion-activated camera and the unmanned surface patrol vehicle.

As a warmup activity before CHTF 2017’s official kick-off, Top 10 Products gained much public attention for the fair. See you at CHTF 2017!


Contacts

China Hi-Tech Fair
Yang Dan, 86 755 8284 8695
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Jack Ma-Backed YF Capital Invested in China’s Largest Offline Data Platform-ZMT

BEIJING--(BUSINESS WIRE)--Beijing Zmeng Network Technology Co.,Ltd. (ZMT), China's largest offline data service platform, has recently announced that it completed series B+ round financing worth 180 million yuan (US$ 27.1 million). YF Capital, founded by Alibaba chairman Jack Ma, led in Series B+ round financing, followed by IDG Capital Partners and Kinzon Capital. To date ZMT has raised 300 million yuan (US$ 45.2 million) in Series B found financing. According to Guang Yuhao, founder and CEO of ZMT, ZMT will focus on "offline data capitalization" after Series B round financing to further promote the upgrading of China's traditional retail industry, sharing economy and other new business types.

ZMT has been favored by a number of institutional investors. Investors in the previous rounds of financing include Fosun and IDG Capital Partners.

Just as Google Analytics analyzes consumers' online data, ZMT helps enterprises acquire offline data through smart hardware and integrate offline data with online data, thereby looking into consumer needs, strengthening management, optimizing services and upgrading marketing. China's traditional retail industry does not know how to acquire and apply mass offline consumer data. ZMT can offer retail enterprises all-round support in data acquisition, synthesis and application, and help them capitalize offline data, thus boosting their competitive advantage in the fast-growing Chinese market. International companies promoting retail industry development through offline data like Euclid and RetailNext are also acquiring offline data through new-generation sensor network and operating on this basis. To promote their advertising business, international giants, such as Google and Facebook, are also working on offline data.

Over the past four years since its founding in 2013, ZMT has focused on the continuous accumulation and value exploration of offline data, established China's largest offline data system, created more than 2 million offline application scenarios, and developed more than 1 million business partners in more than 300 cities. ZMT's offline data capitalization practice application solutions have covered tens of vertical fields including life service, automobile, real estate, education, health, finance and tourism, gaining high recognition from the market. Now ZMT's monthly business revenues are up 200 percent year on year and up 20 percent month on month. ZMT is expected to achieve annual business revenues of hundreds of millions yuan in 2017.

The datamation rate of offline consumer behavior is only 7 percent in China, showing that the Chinese data market is the biggest ever. As China's largest offline data service platform, ZMT can increase the rate to 70-80 percent and the figure will continue to grow. According to the lead investor YF Capital, ZMT is one of the few big data enterprises that can achieve high revenues and profits. It has connected the three links (acquisition, processing and application) of data to build a closed-loop chain, and enjoys prominent advantages of the three links.


Contacts

In China:
Beijing Zmeng Network Technology Co.,Ltd
Xiangning Wang, +8613581993472
wangxiangning@zmeng123.com
Website: www.zmeng.cc

Key Facts About the Global Smart Card IC Market | Technavio

LONDON--(BUSINESS WIRE)--#EmbeddedSystems--The latest market research report by Technavio on the global smart card IC market predicts a CAGR of more than 8% during the period 2017-2021.



The global smart card IC market has been categorized into different segments based on application (telecommunication, financial, government, transportation, and others), microprocessor architecture (16-bit and 32-bit), and geography (the Americas, EMEA, and APAC). It provides a detailed illustration of the major factors influencing the market, including drivers, opportunities, trends, and industry-specific challenges.

Here are some key findings of the global smart card IC market, according to Technavio hardware and semiconductor researchers:

  • Increase in number of financial frauds: a major market driver
  • In 2016, the telecommunication segment dominated the application segments of the market
  • The Americas dominated the global smart card IC market in 2016
  • Infineon Technologies, NXP Semiconductors, Samsung, and STMicroelectronics are the key players

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Market growth analysis

Increase in number of financial frauds across several countries is one of the major factors driving the global smart card IC market. Magnetic tapes are used by most debit cards and credit cards to store data. As these tapes can be easily tampered, it leads to insecure monetary transactions and monetary loss for users. Card skimming, a technique wherein the details of the customer are stolen from the magnetic strip on the cards is an example of frauds that can be carried out using magnetic stripe cards. This information can be used to forge duplicate cards and hence be used to make fraudulent transactions.

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Geographical analysis

According to the Technavio researchers, the Americas has a lesser market share in the global smart card IC market when compared to APAC and EMEA. This is mainly because of the late adoption of Europay Mastercard Visa(EMV) standard in the region. Countries like the US began the adoption of EMV standard in 2015 compared to the countries in EMEA and APAC. The increasing number of financial frauds across the Americas has resulted in the adoption of EMVs. Some of the biggest hacks include the Target in 2013 and Home Depot data breach in 2014. These data breaches compromised the private information of millions of the US citizens.

According to Raghu Raj Singh, a lead analyst at Technavio for research on embedded systems, “In the Americas, the increasing transition towards EMV cards for healthcare systems is one of the key factors driving the smart card IC market. Patients receiving medical treatments from different doctors should undergo complicated paperwork, insurance coverage, and reimbursements. The health savings account (HSA) debit card, which is a tax-advantaged medical savings account for the US citizens has been developed to address this issue. The HSA cards used a magnetic stripe previously but, new versions of the card have integrated a smart card IC into the plastic body. The higher volume of payments, increasing value of each transaction, and the presence of several different payments acceptance systems will drive the adoption of EMV cards in healthcare systems in the US.”

Competitive vendor landscape

There are several major vendors who are present in the global smart card IC market and these vendors dominate the market. This has resulted in a high threat of rivalry. The concentration of these vendors is very high, which prevents new entrants from entering the market. The global smart card IC market is dominated by top four vendors, namely, Infineon Technologies, NXP Semiconductors, STMicroelectronics, and SAMSUNG. The major factors that are considered for the competitive scenario are performance of the product, quality and reliability of the IC, the price of the product, and the possible customization opportunities of the IC.

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About Technavio

Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions.

With over 500 specialized analysts, Technavio’s report library consists of more than 10,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio’s comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

If you are interested in more information, please contact our media team at media@technavio.com.


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China B2C E-Commerce Sales Forecasts 2017-2021 – Research and Markets

DUBLIN--(BUSINESS WIRE)--The "China B2C E-Commerce Sales Forecasts: 2017 to 2021" report has been added to Research and Markets' offering.


China is the world's largest B2C E-Commerce market, accounting for a double-digit share of global online sales. More than half a billion people shop online in China, with the E-Commerce share of total retail sales reaching twice as high as the global average. Within the next few years, China is expected to set a new record by generating E-Commerce sales of over 1 trillion Euros, including B2C and C2C online retail. Five out of six original sources cited in this publication concur with this prediction, although disagree on the specific year when this milestone will be reached. Another common projection is the decline of year-on-year growth rates over the forecast period compared to the previous years due to increased maturity of the market, although the compound annual growth rate in the period from 2016 to 2021 is still projected to remain in the double-digits.

Among the key drivers of the online retail sales growth in China is the rise of mobile shopping as the main mode of E-Commerce. In the first half of 2017, M-Commerce accounted for more than three-quarters of online retail sales in China, according to several market estimates cited in the report. The convenience of mobile shopping is expected to further spur the overall E-Commerce growth over the forecast period. Another major growth driver is the proliferation of online shopping in smaller cities and rural areas. Between 2015 and 2016, E-Commerce sales in rural China more than doubled, but still accounted for less than one-fifth of the nationwide online retail sales. Considering the significant proportion of China's population living in rural areas, higher Internet and online shopper penetration rates combined with the expansion of delivery coverage of the major market players is projected to contribute to the E-Commerce boom.

Questions Answered in this Report:

  • How large is China's online retail market predicted to be by 2021?
  • What growth rates are expected for retail E-Commerce sales in China through 2021?
  • What are the main E-Commerce growth drivers in China?
  • How high China's share of global online sales in 2016 and what is the forecast for 2021?
  • Which percentage of retail E-Commerce sales in China stems from mobile in 2017?

Key Topics Covered:

1. Management Summary

2. Market Overview and International Comparisons

3. Overview of Sales and Shares Forecasts

4. Sales Forecasts

Companies Mentioned

  • Alibaba Group
  • Amazon.com Inc
  • Apple Inc
  • Facebook Inc
  • Google LLC
  • PayPal Holdings Inc
  • Samsung Electronics Co. Ltd
  • Wal-Mart Stores Inc.

For more information about this report visit https://www.researchandmarkets.com/research/jvwlvz/china_b2c


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APAC to Dominate the Automotive Transmission Dynamometer Market | Technavio

LONDON--(BUSINESS WIRE)--#Automotive--The latest market research report by Technavio on the global automotive transmission dynamometer market predicts a CAGR of more than 29% during the period 2017-2021.



The report segments the global automotive transmission dynamometer market by geography, including the Americas, EMEA, and APAC. It provides a detailed illustration of the major factors influencing the market, including drivers, opportunities, trends, and industry-specific challenges.

Here are some key findings of the global automotive transmission dynamometer market, according to Technavio automotive researchers:

  • Increasing vehicle population and rapid growth in APAC: a major market driver
  • Potential increase in HEV and EV population to impact dynamometer testing
  • In 2016, APAC held the largest market share of close to 52%, followed by the Americas and EMEA
  • SuperFlow Dynamometers & Flowbenches, Meidensha, HORIBA MIRA, SAKOR Technologies, Taylor Dynamometer, and Power Test are the key vendors

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Market growth analysis

The automotive industry is witnessing favorable conditions across multiple geographies. The vehicle production numbers, which include passenger cars and commercial vehicles, stood at 94.29 million units in 2016. This is one of the major factors driving the global automotive transmission dynamometer market. APAC is the fastest-growing vehicle market in terms of both production and consumption. Therefore, the expansion of existing production facilities and the rapid additions of production facilities in APAC will drive the market for automotive test equipment, such as dynamometers. The rise in demand for automobile restoration, especially in the fast-growing markets like India and China, is expected to further drive the market for engine dynos.

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Geographical analysis

Technavio researchers anticipate high growth for the global automotive transmission dynamometer market in APAC as the region serves as the largest automotive component-manufacturing hub. Rising demand for vehicles from countries, such as China, South Korea, and India, is attracting global automotive manufacturers to invest in and operate from these countries, driving the need for testing equipment. Technological advancements, in terms of the development of engines, powertrains, alternative fuel technologies, stringent emission norms, in addition to the steady automobile production in the Americas and EMEA are boosting the automotive transmission dynamometer market.

According to Neelam Barua, a lead analyst at Technavio for research on automotive services, “Promising economic growth potential in emerging countries is boosting the number of market opportunities for passenger cars, thereby, attracting global automobile manufacturers to this region. While market players are investing in technology to drive innovation in engines and powertrains, they are also expanding production facilities and setting up new facilities to cater to growing regional demand and beyond. These factors are increasing demand for automotive test equipment, including dynamometers.”

Competitive vendor landscape

The automotive industry increasingly demands continuous innovations in products and manufacturing processes. Consumers highly value the durability and reliability factors of vehicles, and these determine the reputation of the brand. Therefore, automotive test equipment will continue to be critical in delivering and exceeding customers' expectations through the concept of automotive test equipment. The dynamism in the industry is also helping in driving testing requirements and evolving the need for high-performance equipment. This, in turn, is generating several market opportunities for vendors operating in this space.

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Development of the Indian ESDM (Electronics System Design and Manufacturing) Industry, 2017-2020 – Research and Markets

DUBLIN--(BUSINESS WIRE)--The "Development of the Indian ESDM (Electronics System Design and Manufacturing) Industry" report has been added to Research and Markets' offering.


Government of India projected in 2012 that the Indian ESDM (Electronics System Design and Manufacturing) market, consisting of electronics products, electronics components, semiconductor design, electronics manufacturing services, semiconductor fabrication, and equipment manufacturing, would reach USD 400 billion by 2020.

This report provides an introduction into the development of the ESDM industry and market across different areas and segments such as mobile phone, TV, STB (Set Top Box), LED lighting, automotive electronics, and power sector/renewable energy; examines the government policies proposed for the ESDM development and promotion with an aim to identify business opportunities for electronics companies intending and willing to invest in India.

List of Topics:

  • Introduction to the ESDM (Electronics System Design and Manufacturing) industry, touching six major sectors which include electronics products, electronics components, semiconductor design, electronics manufacturing services, semiconductor fabrication, and equipment manufacturing
  • Development of the ESDM market, touching on its market value and market share by segment for the period 2012-2015, as well as the forecast market value until 2022; the segments include mobile phone, TVs, STB (Set Top Box), LED lighting, automotive electronics, and power sector/renewable energy
  • The Indian government's plans for the industry, including the national policy, strategic planning, and incentives for promoting electronics manufacturing in India, government policies in top 10 Indian states, and type of initiatives proposed by MeitY (Ministry of Electronics and Information Technology)
  • Development and objectives of the electronics manufacturing clusters and includes a case study that took place in Telangana

Key Topics Covered:

  1. Introduction to the ESDM Industry
  2. Electronics Market in India
  3. Import Burdens on Electronics Products
  4. National Policy on Electronics
  5. Electronics Manufacturing Clusters
  6. States Incentives for Electronics Manufacturing

For more information about this report visit https://www.researchandmarkets.com/research/tz4k9c/development_of


Contacts

Research and Markets
Laura Wood, Senior Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
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Related Topics: Electrical Engineering

Taiwanese Notebook PC Industry, 3Q 2017 Report – Research and Markets

DUBLIN--(BUSINESS WIRE)--The "Taiwanese Notebook PC Industry, 3Q 2017" report has been added to Research and Markets' offering.


The report finds that owing mainly to the commercial replacement demand from the United States, the Taiwanese notebook PC industry had a shipment volume of 32.3 million units in the second quarter of 2017, enjoying both sequential and year-on-year growth. The industry's shipment volume is expected to have grown sequentially in the third quarter of 2017, to approximately 34.4 million units. The growth is likely to continue well into the fourth quarter of 2017 albeit at a slower rate.

List of Topics:

  • This research report presents shipment volume and value forecast, and recent quarter review of the Taiwanese notebook PC industry, covering mainly ODM, OEM, EMS, OBM, and private label makers.
  • The report includes shipment volume and value, ASP, manufacturer volume ranking, shipment by assembly level, shipment by price point, and product mix analysis.
  • The content of this report is based on primary data obtained through interviews with Taiwan's notebook PC makers which have production facilities in Taiwan and/or China.

Companies Mentioned

  • AMD
  • ASUS
  • Acer
  • Apple
  • Clevo
  • Compal
  • Dell
  • ECS
  • Foxconn
  • Fujitsu
  • HP
  • Intel
  • Inventec
  • Lenovo
  • MSI
  • Pegatron
  • Quanta
  • Sony
  • Toshiba
  • Wistro

For more information about this report visit https://www.researchandmarkets.com/research/8q9n7m/taiwanese


Contacts

Research and Markets
Laura Wood, Senior Manager
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For E.S.T Office Hours Call 1-917-300-0470
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Related Topics: Laptops and Notebooks

Rising Advantage of Public Private Partnership in India & Project Database on PPP Model – Research and Markets

DUBLIN--(BUSINESS WIRE)--The "Rising Advantage of Public Private Partnership in India & Project Database on PPP Model" report has been added to Research and Markets' offering.


Examining and Harnessing Opportunities under Transportation Projects - Roads & Highways, Power, Railways, MRTS, Airports, Ports, Irrigation, Education and Healthcare Segment in India

Of all the sectors within infrastructure, transport has received the highest sum in the 2017-18 budget - US$35 billion - much of it aimed at improving safety, cleanliness and comfort for rail passengers. Among the top priorities are a passenger safety fund, an end to unmanned level crossings on broad gauge lines, solar power for more than 7000 railway stations, bio-toilets in all coaches, and an extensive station development and refurbishment plan, including access for differently-abled people through elevators and escalators.

Government in India is striving for balancing fiscal prudence with economic growth and this boost is likely to enthuse more private investments especially in the infrastructure segment and the case for PPP projects scores up. Simply for a reason to increase the private investment the environment offered for such capital intensive segments do demand risk hedging which PPP does provide. However, PPP in so far status have had mixed response with initial years witnessing a limited success and that too local to roads & highways and power sector only. When we factor in a US$1.5 billion recapitalization of public banks - with further funds promised - then hopefully there should be more credit available to fund essential projects which fall under the infra segment.

Key Queries Resolved:

  • What is the opportunity size as per investments under different segments which are apt for PPP model in India?
  • What shall be the opportunity under PPP model and tracking projects on state wise basis for irrigation & dam segment?
  • What shall be the opportunity under PPP model and tracking projects on state wise basis for Railways and MRTS systems?
  • What shall be the opportunity under PPP model on state wise basis for roads & highways segment?
  • What shall be the opportunity under PPP model and tracking projects on state wise basis for ports & airports segment?
  • What shall be the opportunity under PPP model and tracking projects on state wise basis for conventional power and renewable segment and new sector of energy efficiency and electric vehicle promoting projects?
  • What shall be the region wise best state for PPP projects in India under different segments in India
  • Why PPP model can be viable for future in India as per budgetary allocations in India?

Key Highlights:

  • Examining the performance review and understanding dynamics of PPP Projects in India
  • Evaluating key challenges under seamless implementation of PPP projects in India
  • Impact of Government schemes for SAUBHGHYA & EVs upon the PPP segment
  • Examining region wise best state for PPP projects in India
  • Examining PPP Opportunity in Railways Sector in India- Upcoming till FY 2022
  • Examining PPP Opportunity in Roads & Highways Sector in India- Upcoming till FY 2022
  • Examining PPP Opportunity in Conventional & Renewable Sector in India- Upcoming till FY 2022
  • Examining PPP Opportunity in Healthcare Sector in India- Upcoming till FY 2022

For more information about this report visit https://www.researchandmarkets.com/research/f2q3hp/rising_advantage


Contacts

Research and Markets
Laura Wood, Senior Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
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Related Topics: Infrastructure Construction

World Helicopters Market Report 2017 – Analysis and Forecast to 2025 – Research and Markets

DUBLIN--(BUSINESS WIRE)--The "World: Helicopters - Market Report - Analysis and Forecast to 2025" report has been added to Research and Markets' offering.


The report provides an in-depth analysis of the global helicopter market. It presents the latest data of the market size and volume, domestic production, exports and imports, price dynamics and turnover in the industry. The report shows the sales data, allowing you to identify the key drivers and restraints. You can find here a strategic analysis of key factors influencing the market. Forecasts illustrate how the market will be transformed in the medium term. Profiles of the leading companies and brands are also included.

Product Coverage:

  • Helicopter of an unladen weight not exceeding 2,000 kg.
  • Helicopter of an unladen weight exceeding 2,000 kg.

Key Topics Covered:

1. Introduction

1.1 Report Description

1.2 Research Methodology

2. Executive Summary

2.1 Key Findings

2.2 Market Trends

3. Market Overview

3.1 Market Volume And Value

3.2 Consumption By Country

3.3 Market Opportunities By Country

3.4 Market Forecast To 2025

4. Production

4.1 Production From 2007-2016

4.2 Production By Country

5. Imports

5.1 Imports From 2007-2016

5.2 Imports By Country

5.3 Import Prices By Country

6. Exports

6.1 Exports From 2007-2016

6.2 Exports By Country

6.3 Export Prices By Country

7. Profiles Of Major Producers

For more information about this report visit https://www.researchandmarkets.com/research/rkf4mc/world


Contacts

Research and Markets
Laura Wood, Senior Manager
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For E.S.T. Office Hours Call 1-917-300-0470
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For GMT Office Hours Call +353-1-416-8900
Related Topics: Aircraft

A.M. Best Maintains Under Review With Developing Implications Status for Credit Ratings of Macau Life Insurance Company Limited

HONG KONG--(BUSINESS WIRE)--A.M. Best has maintained the under review with developing implications status for the Financial Strength Rating of B++ (Good) and the Long-Term Issuer Credit Rating of “bbb” of Macau Life Insurance Company Limited (MLIC) (Macau).


The developing implications status reflects the possibility that these Credit Ratings (ratings) may change, although the direction of any ratings change is uncertain.

Maintaining the under review status is a follow-up to the rating actions taken by A.M. Best on Nov. 17, 2016. On June 2, 2016, Dah Sing Financial Holdings Limited and Macau Insurance Company Limited announced that they agreed to sell 100% of MLIC’s shares to Thaihot Investment (Bermuda) Company Limited (Thai Hot) (Bermuda). MLIC is expected to maintain its current distribution relationship with Banco Comercial de Macau, S.A. after the closing of the transaction. Although the acquisition was completed on Nov. 9, 2017, the extended under review status reflects the uncertainty regarding Thai Hot’s credit profile and how future business plans could impact MLIC.

MLIC’s ratings will remain under review until A.M. Best completes its discussions with the company’s management team. In addition, any potential rating impact from actual or anticipated changes to MLIC’s credit profile and business plans will be assessed. A.M. Best will factor its view of Thai Hot’s credit profile into the final rating determination.

Ratings are communicated to rated entities prior to publication. Unless stated otherwise, the ratings were not amended subsequent to that communication.

This press release relates to Credit Ratings that have been published on A.M. Best’s website. For all rating information relating to the release and pertinent disclosures, including details of the office responsible for issuing each of the individual ratings referenced in this release, please see A.M. Best’s Recent Rating Activity web page. For additional information regarding the use and limitations of Credit Rating opinions, please view Understanding Best’s Credit Ratings. For information on the proper media use of Best’s Credit Ratings and A.M. Best press releases, please view Guide for Media - Proper Use of Best’s Credit Ratings and A.M. Best Rating Action Press Releases.

A.M. Best is the world’s oldest and most authoritative insurance rating and information source. For more information, visit www.ambest.com.

Copyright © 2017 by A.M. Best Rating Services, Inc. and/or its subsidiaries. ALL RIGHTS RESERVED.


Contacts

A.M. Best
Vivian Cheung, +852 2827 3421
Senior Financial Analyst
vivian.cheung@ambest.com
or
Christie Lee, +852 2827 3413
Director, Analytics
christie.lee@ambest.com
or
Christopher Sharkey, +1 908 439 2200, ext. 5159
Manager, Public Relations
christopher.sharkey@ambest.com
or
Jim Peavy, +1 908 439 2200, ext. 5644
Director, Public Relations
james.peavy@ambest.com

CDB Aviation Delivers One New 737-800 to Air Changan

Lessor Continues to Strengthen Operations and Deliver Best-in-Class Financing Solutions to Airlines in China and Beyond

SEATTLE--(BUSINESS WIRE)--#AirChangan--CDB Aviation Lease Finance DAC (“CDB Aviation”), a wholly owned Irish subsidiary of China Development Bank Financial Leasing Co., Limited (“CDB Leasing”), announced that a domestic Chinese carrier Air Changan took delivery of its first new Boeing 737-800 aircraft on lease from CDB Aviation at a handover ceremony on November 16 at Boeing Field in Seattle.


“We are very pleased to welcome Air Changan as our newest lessee customer in China and provide the airline with its first new 737-800 aircraft to further expand its fleet and continue enhancing efficiency of its route network with the aircraft’s optimized operating performance,” said CDB Aviation President and Chief Executive Officer Peter Chang.

This is the first time Air Changan took delivery of a new 737-800 aircraft, which will join the Shaanxi Province-based carrier’s 737-800-only fleet and will be operated from Xian Xianyang International Airport on services to regional destinations.

“It’s a pleasant cooperation with CDB Aviation. The new introduced aircraft B-1481 is the eighth 737-800 aircraft of Air Changan. Since launching the first flight on May 9, 2016, Air Changan has got a rapid development and opened 32 domestic routes, reaching 33 destinations,” commented Air Changan President Kong Xiangyu. “We will keep introducing aircraft, enrich our route network, provide more convenience for the public and make Air Changan the biggest mid-long distance dynamic culture airline.”

“Boeing 737s are the most popular airplanes in the world and we are delighted to see lessors like CDB Aviation and carriers like Air Changan utilize the airplane’s leading reliability, range and efficiency to grow their business,” said Jeremy Griffin, Boeing Senior Vice President of Global Leasing Sales.

During the 2017 Paris Air Show, the lessor joined the ranks of the launch customers for the 737 MAX 10 aircraft, signing a Memorandum of Understanding with Boeing for ten 737 MAX 10s and forty-two 737 MAX 8s.

“CDB Aviation is bringing an exciting new platform to serve the airline community—we are committed to building a best-in-class global aviation financier,” added Chang. “We are thrilled with our progress to date and look forward to delivering greater value to our airline customers in China and beyond.”

CDB Aviation’s growing aircraft portfolio comprises 210 aircraft, with an average age of approximately 4.5 years, placed with 45 customers across 25 countries. The lessor’s forward order book consists of 201 aircraft committed with both Boeing and Airbus. In addition to the 737NG and MAX families, the lessor’s order book includes Boeing 787s as well as the Airbus A320ceo and A320neo families.

About CDB Aviation

CDB Aviation Lease Finance DAC (“CDB Aviation”) is a wholly owned Irish subsidiary of China Development Bank Financial Leasing Co., Limited (“CDB Leasing”) a 33-year-old Chinese leasing company that is backed mainly by the China Development Bank. China Development Bank is under the direct jurisdiction of the State Council of China and is the world’s largest development finance institution. It is also the largest Chinese bank for foreign investment and financing cooperation, long-term lending and bond issuance, enjoying Chinese sovereign credit rating. www.CDBAviation.AERO

CDB Leasing is the only leasing arm of the China Development Bank and a leading company in China’s leasing industry that has been engaged in aircraft, infrastructure, ship, commercial vehicle and construction machinery leasing and enjoys a Chinese sovereign credit rating. It took an important step in July 2016 to globalize and marketize its business – listing on the Hong Kong Stock Exchange (HKEX STOCK CODE: 1606).


Contacts

CDB Aviation Lease Finance DAC
Paul Thibeau, +1-612-594-9844
Paul.THIBEAU@CDBALF.com

Global Industrial IoT Market Size, Trends & Forecasts 2017-2021 – Research and Markets

DUBLIN--(BUSINESS WIRE)--The "Global Industrial IoT Market: Size, Trends & Forecasts (2017-2021)" report has been added to Research and Markets' offering.


Global Industrial IoT Market: Size, Trends & Forecasts (2017-2021), provides analysis of the global Industrial IoT market, with detailed analysis of market size and growth, and segmentation of the industry. The analysis includes the market by value, by segments and by region. The report also provides the analysis of the global Industrial IoT market of the EMEA, Germany and China regions.

Moreover, the report also assesses the key opportunities in the market and outlines the factors that are and will be driving the growth of the industry. Growth of the overall global Industrial IoT market has also been forecasted for the years 2017-2021, taking into consideration the previous growth patterns, the growth drivers and the current and future trends.

General Electric, Intel Corporation, Cisco Systems, Inc. and Honeywell International, Inc. are some of the key players operating in the global Industrial IoT market, whose company profiling has been done in the report. In this segment of the report, business overview, financial overview and business strategies of the companies are provided.

Market Dynamics

Growth Drivers

  • Booming Economic Growth
  • Rise of LPWA Network Technology
  • Rising IoT Platform, Application and Security Spending
  • Surging Demand of COBOT
  • Decreasing Average price of IC Sensors
  • Wireless Sensor Technology

Challenges

  • Complexity in Implementation
  • Lack of Skills
  • Safety and Privacy of Data Concerns
  • Lack of Reliability and Scalability
  • Intricacy in Data Management

Market Trends

  • 5G New Radio (NR) Technology
  • Smart Dust
  • Virtual Simulation of Products
  • Intelligent Factories
  • Cloud Robotics

Key Topics Covered:

1. Executive Summary

2. Introduction

3. Global Market Analysis

4. Regional Market Analysis

5. Market Dynamics

6. Competitive Landscape

7. Company Profiling

  • Cisco Systems
  • General Electric
  • Honeywell International, Inc.
  • Intel Corporation

For more information about this report visit https://www.researchandmarkets.com/research/hz26mj/global_industrial


Contacts

Research and Markets
Laura Wood, Senior Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Internet of Things and M2M